Washington University Lupus Center

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect any organ of the body. Lupus nephritis is a severe manifestation of SLE that, if left untreated, can lead to progressive decline in kidney function and end-stage kidney diseases.

Washington University offers SLE patients a multidisciplinary approach to diagnosis and treatment of SLE. Our dedicated Washington University Lupus Center enables patients to receive care from various lupus specialists in one location during a single visit.

Specialists include:

  • Nephrologists
  • Rheumatologists
  • Dermatologists

The Lupus Center also collaborates with specialists from Cardiology, Orthopedic Surgery, high-risk Obstetrics, Gynecology, and Ophthalmology to improve the coordination of additional subspecialty care.

Glomerular Diseases Clinic/Renal Biopsy Outreach Program

Glomerular diseases are a well-recognized cause of chronic kidney disease and end-stage renal disease. The diseases are rare and require accurate diagnosis, as well as highly specialized care.

Washington University has a team of experienced nephrologists with extensive experience and expertise in the diagnosis and treatment of glomerular diseases, as well as in the management of therapy-related complications. For patients and referring physicians that need a thorough evaluation and subsequent treatment plan, the university has a Renal Biopsy Outreach Program, which serves as a regional consultative service focused on the evaluation and treatment of glomerular diseases.

Upon request, Washington University nephrologists perform renal biopsies and provide consultation on disease management in a timely manner. Washington University also has a dedicated and experienced renal pathologist interpreting the tissue biopsies using state-of-the-art technology and with a rapid turnaround time of 24 hours.

Glomerular diseases we evaluate and treat include:

  • Lupus nephritis
  • Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides
  • Cryoglobulinemic vasculitis
  • Goodpasture’s disease/anti-glomerular basement membrane (GBM) antibody disease
  • IgA nephropathy
  • Membranoproliferative glomerulonephritis (MPGN)
  • C3 glomerulopathy/Dense-deposit disease
  • Atypical HUS
  • Membranous nephropathy
  • Focal segmental glomerulosclerosis (FSGS)
  • Minimal change disease
  • Alport syndrome/hereditary nephritis
  • Fibrillary glomerulonephritis/immunotactoid glomerulopathy
  • Paraproteinemias (amyloid/myeloma-related renal diseases)

Clinical trials

In addition to comprehensive patient care, clinical research under way at Washington University is focused on the identification and evaluation of safer and more effective therapies for lupus nephritis, primary focal segmental glomerulosclerosis, ANCA-associated vasculitis, idiopathic membranous nephropathy, and IgA nephropathy. Patients are able to participate in these clinical trials while remaining under the care of their own nephrologist.

For information on glomerular disease clinical trials, please contact:

Marta Santos, RN, BSN
Clinical Research Nurse Coordinator
Phone: 314-362-8445
Pager: 314-424-7690

Tingting Li, MD
Associate Professor of Medicine
Phone: 314-362-7211
Pager: 314-253-1786

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