Eirini Kefalogianni, PhD

Instructor of Medicine, Division of Nephrology

Mailing Address

Division of Nephrology

  • Mailing Address: 660 S. Euclid Ave., CB 8126
    St. Louis, MO 63110

Education

  • Bachelor of Science, Biology: University of Athens, Greece
  • PhD, Physiology/Cellular Signaling: University of Athens, Greece
  • Postdoctoral, Cardiovascular Physiology/Cell Signaling: New York University School of Medicine, New York, NY
  • Postdoctoral, Renal Pathophysiology/Cell Signaling: Harvard Medical School, Brigham and Women’s Hospital, Boston, MA

Research Interests

Molecular mechanisms of kidney injury, repair and fibrosis; growth factor signaling; cytokine signaling; systemic effects of kidney injury.

Publications

Kefaloyianni E, Keerthi Raja MR, Schumacher J, Muthu ML, Krishnadoss V, Waikar SS, Herrlich A. Proximal tubule-derived amphiregulin amplifies and integrates profibrotic EGFR signals in kidney fibrosis. J Am Soc Nephrol 2019 Dec;30(12):2370-2383. doi: 10.1681/ASN.2019030321.

Chang-Panesso M, Kadyrov FF, Lalli MA, Wu H, Ikeda S, Kefaloyianni E, Abdelmageed MM, Herrlich A, Kobayashi A, Humphreys BD. FoxM1 drives proximal tubule proliferation during repair from acute ischemic kidney injury. J Clin Invest, 2019 Dec 2;129(12):5501-5517. doi: 10.1172/JCI125519.

Herrlich A, Kefaloyianni E. iRhoms: A Potential Path to More Specific Therapeutic Targeting of Lupus Nephritis. Am J Kidney Dis. 2018 Oct;72(4):617-619. doi: 10.1053/j.ajkd.2018.04.010.

Wilson JL, Kefaloyianni E, Stopfer L, Harrison C, Sabbisetti V, Fraenkel E, Lauffenburger DA, Herrlich A. Functional Genomics Approach Identifies Novel Signaling Regulators of TGFα Ectodomain Shedding. Mol Cancer Res. 2018: 16(1):147-161.

Kefaloyianni E, Muthu ML, Kaeppler J, Sun XM, Sabbisetti V, Chalaris A, Rose-John S, Wong E, Sagi I, Waikar SS, Rennke H, Humphreys BD, Bonventre JV, Herrlich A. ADAM17 substrate release in proximal tubule drives kidney fibrosisJCI Insight. 2016: 1(13):e87023. doi:10.1172/jci.insight.87023.

Azzi J, Yin Q, Uehara M, Ohori S, Tang L, Cai K, Ichimura T, McGrath M, Maarouf O, Kefaloyianni E, Loughhead S, Petr J, Sun Q, Kwon M, Tullius S, von Andrian UH, Cheng J, Abdi R. Targeted Delivery of Immunomodulators to Lymph NodesCell Rep. 2016: 15(6):1202-13.

Mounayar M*, Kefaloyianni E*, Smith B, Maarouf OH, Solhjou Z, Azzi Z, Chabtini L, Fiorina P, Kraus M, Briddell R, Fodor W, Herrlich A and Abdi R. PI3Kα and STAT1 interplay regulates human mesenchymal stem cell immune polarizationStem Cells. 2015: 33(6):1892-901.

Ben Nasr M, Vergani A, Avruch J, Liye L, Kefaloyianni E, D’Addio F, Tezza S, Corradi D, Bassi R, Valderrama-Vasquez A, Usuelli V, Kim J, Azzi J, El Essawy AB, Markmann J, Abdi R, Fiorina P. Co-transplantation of autologous MSCs delays islet allograft rejection and generates a local immunoprivileged site.” Acta Diabetol. 2015: 52(5):917-27.

Kefaloyianni E*, Lyssand JS*, Moreno C, Delaroche D, Hong M, Fenyö D, Mobbs CV, Neubert TA and Coetzee WA. “A comparative proteomics analysis of the KATP channel complex in different tissue types.” Proteomics 2013: 13:368-78.

Yoshida H, Bao L, Kefaloyianni E, Taskin E, Okorie U, Hong M, Dhar-Chowdhury P, Kaneko M, Coetzee WA. AMP-activated protein kinase connects cellular energy metabolism to KATP channel functionJ Mol Cell Cardiol. 2012: 52(2): 410-8.

Hong M, Bao L, Kefaloyianni E, Agullo-Pascual E, Chkourko H, Foster M, Taskin E, Zhandre M, Reid DA, Rothenberg E, Delmar M, Coetzee WA. Heterogeneity of ATP-Sensitive K+ Channels in Cardiac Myocytes: Enrichment at the Intercalated DiskJ Biol Chem. 2012: 287:41258-41267.

Kefaloyianni E, Bao L, Rindler MJ, Hong M, Patel T, Taskin E and Coetzee WA. Measuring and Evaluating the Role of ATP-Sensitive K+ Channels in Cardiac MuscleJ Mol Cell Cardiol. 2012: 52(3):596-607.

Lader JM, Vasquez C, Bao L, Maass K, Qu J, Kefalogianni E, Fishman GI, Coetzee WA, Morley GE. Remodeling of atrial ATP-sensitive K+ channels in a model of salt-induced elevated blood pressureAm J Physiol Heart Circ Physiol. 2011: 301(3):H964-74.

Bao L, Kefaloyianni E, Lader J, Hong M, Morley G, Fishman GI, Sobie EA and Coetzee WA. Unique Properties of the ATP-Sensitive K+ Channel in the Mouse Ventricular Cardiac Conduction SystemCirc Arrhythm Electrophysiol. 2011: 4(6):926-35.

Hong M*, Kefaloyianni E*, Bao L, Malester B, Delaroche D, Neubert TA and Coetzee WA. Cardiac ATP-sensitive K+ channel associates with the glycolytic enzyme complex. FASEB J. 2011: 25(7):2456-2467.

Kefaloyianni E and Coetzee WA. Transcriptional remodeling of ion channel subunits by flow adaptation in human coronary artery endothelial cellsJ Vasc Res. 2011: 48: 357-367.

Aggeli IK, Kefaloyianni E, Beis I and Gaitanaki C. HOX-1 and COX-2: Two differentially regulated key mediators of skeletal myoblast tolerance under oxidative stress. Free Radic Res. 2010: 44: 679-93.

Kefaloyianni E, Gaitanaki C and Beis I. ERK1/2 and p38-MAPK signaling pathways, through MSK1, are involved in NF-κB trans-activation during oxidative stress in skeletal myoblasts. Cell Signal. 2006: 18: 2238-2251.

Kefaloyianni E, Gourgou E, Ferle V, Kotsakis E, Gaitanaki C and Beis I. Acute thermal stress and various heavy metals induce tissue-specific pro- or anti-apoptotic events via the p38-MAPK signal transduction pathway in Mytilus galloprovincialis (Lam.) J. Exp. Biol. 2005: 208: 4427-4436.

Gaitanaki C, Kefaloyianni E, Marmari A and Beis I. Various stressors rapidly activate the p38-MAPK signaling pathway in Mytilus galloprovincialis (Lam.) Mol. Cell. Biochem. 2004: 260: 119-127.

*denotes equal contribution