Steven Funk, PhD

Instructor of Medicine, Division of Nephrology

Mailing Address

Division of Nephrology

  • Mailing Address: 660 S. Euclid Ave., CB 8126
    St. Louis, MO 63110

Education

  • 2016 – 2018     Post-doctoral research associate, Washington University, St. Louis, Missouri
  • 2013 – 2016     Post-doctoral scholar (T32), Washington University, St. Louis, Missouri
  • 2007 – 2013     Pre-doctoral research associate, LSU Health Sciences Center, Shreveport, LA
  • 2007 – 2013     PhD,  Cell Biology and Anatomy, Vascular Disease, LSU Health Sciences Center, Shreveport, LA
  • 2000 – 2005     BS,  Microbiology, University of Louisiana, Lafayette, LA

Research Interests

Diseases of the glomerular basement membrane, in particular, Alport and Pierson syndromes.

Professional Societies and Organizations

  • 2013 – Pres      American Society of Nephrology
  • 2012 – Pres      American Society of Matrix Biology
  • 2011 – 2013     North American Vascular Biology Organization
  • 2009 – 2013     American Heart Association

Teaching Responsibilities

  • 2018 – 2018     Adjunct Instructor, Cardiovascular functions, diseases, and therapeutics; Course #Bio483, University College, Washington University in St. Louis
  • 2018 – 2018     Adjunct Instructor, Readings and Research Course #Bio458, University College, Washington University in St. Louis
  • 2016 – 2018     Teaching Assistant, Introduction to Problem Based Learning in Biology Course #Bio112/427, Washington University
  • 2009 – 2011     Teaching Assistant, Cardiovascular Histology, LSU Health Sciences Center School of Graduate Studies

Publications

Funk SD, Bayer RH, McKee KK, Okada K, Nishimune H, Yurchenco PD, Miner JH. A deletion in the N-terminal polymerizing domain of laminin β2 is a new mouse model of chronic nephrotic syndrome. Kidney Int.  Accepted, 2020

Funk SD, Bayer RH, Miner JH. Endothelial cell-specific collagen type IV-α3 expression does not rescue Alport syndrome in Col4a3-/-.  Am J Physiol Renal Physiol. 2019; 316(5):F830-F837.PMCID:PMC6580247 PMID:30724107

Funk SD, Lin MH, Miner JH. Alport syndrome and Pierson syndrome: Diseases of the glomerular basement membrane.  Matrix Biol. 2018; 71-72:250-261.PMCID:PMC6146048 PMID:29673759

Funk SD, Finney AC, Yurdagul A Jr, Pattillo CB, Orr AW. EphA2 stimulates VCAM-1 expression through calcium-dependent NFAT1 activity. Cell Signal. 2018;49:30-38. PMCID:PMC6680248PMID:29793020

Funk SD, Bayer RH, Malone AF, McKee KK, Yurchenco PD, Miner JH. Pathogenicity of a Human Laminin β2 Mutation Revealed in Models of Alport Syndrome. J Am Soc Nephrol. 2018;29(3):949-960.PMCID:PMC5827610 PMID:29263159

Finney AC, Funk SD, Green JM, Yurdagul A Jr, Rana MA, Pistorius R, Henry M, Yurochko A, Pattillo CB, Traylor JG, Chen J, Woolard MD, Kevil CG, Orr AW. EphA2 Expression Regulates Inflammation and Fibroproliferative Remodeling in Atherosclerosis. Circulation. 2017;136(6):566-582.PMCID:PMC5548618 PMID:28487392

Malone AF, Funk SD, Alhamad T, Miner JH. Functional assessment of a novel COL4A5 splice region variant and immunostaining of plucked hair follicles as an alternative method of diagnosis in X-linked Alport syndrome. Pediatr Nephrol. 2017;32(6):997-1003.PMCID:PMC5400701 PMID:28013382

Funk SD, Miner JH. Muscular dystrophy meets protein biochemistry, the mother of invention. J Clin Invest. 2017;127(3):798-800.PMCID:PMC5330736 PMID:28218619

Yurdagul A Jr, Chen J, Funk SD, Albert P, Kevil CG, Orr AW. Altered nitric oxide production mediates matrix-specific PAK2 and NF-κB activation by flow. Mol Biol Cell. 2013;24(3):398-408.PMCID:PMC3564533 PMID:23171552

Funk SD, Orr AW. Ephs and ephrins resurface in inflammation, immunity, and atherosclerosis. Pharmacol Res. 2013;67(1):42-52.PMID:23098817

Funk SD, Yurdagul A Jr, Albert P, Traylor JG Jr, Jin L, Chen J, Orr AW. EphA2 activation promotes the endothelial cell inflammatory response: a potential role in atherosclerosis. Arterioscler Thromb Vasc Biol. 2012;32(3):686-95.PMCID:PMC3325141 PMID:22247258

Funk SD, Yurdagul A Jr, Orr AW. Hyperglycemia and endothelial dysfunction in atherosclerosis: lessons from type 1 diabetes. Int J Vasc Med. 2012;2012:569654.PMCID:PMC3303762 PMID:22489274

Chen S, Wassenhove-McCarthy D, Yamaguchi Y, Holzman L, van Kuppevelt TH, Orr AW, Funk S, Woods A, McCarthy K. Podocytes require the engagement of cell surface heparan sulfate proteoglycans for adhesion to extracellular matrices. Kidney Int. 2010;78(11):1088-99.PMCID:PMC3125125 PMID:20463653

Funk SD, Yurdagul A Jr, Green JM, Jhaveri KA, Schwartz MA, Orr AW. Matrix-specific protein kinase A signaling regulates p21-activated kinase activation by flow in endothelial cells. Circ Res. 2010;106(8):1394-403.PMCID:PMC2862370 PMID:20224042