Additional Titles

• Professor of Developmental Biology

Mailing Address

Education

• Undergraduate: Queen’s College, Georgetown, Guyana (1954-1063)
• Graduate: Royal College of Surgeons, Ireland, L.R.C.P. & S.I. (1964-1970)
• MBBS: University of London (1965-1970)
• Externship: Hamilton General Hospital, McMaster University, Hamilton, Ontario, Canada (1969)
• Internship: Barnes Hospital, Washington University School of Medicine, St. Louis, MO (1970-1971)
• Residency: Barnes Hospital, Washington University School of Medicine, St. Louis, MO (1971-1973)
• Postdoctoral Clinical Research Fellow, Nephrology: Barnes Hospital, Washington University School of Medicine, St. Louis, MO (1973-1975)
• Postdoctoral Research Fellow in Pharmacology: Barnes Hospital, Washington University School of Medicine, St. Louis, MO (1976-1978)

Board Certifications

• Internal Medicine, 1973
• Nephrology, 1976

Recognition

1966
Kane Memorial Gold Medal in Biochemistry
Evatt Memorial Medal in Anatomy

1967
Stoney Memorial Gold Medal in Anatomy

1970
Dominic Corrigan Prize in Medicine May

1973-1975
Fellowship of the National Kidney Foundation

1976
Fellow, Royal College of Physicians of Canada (FRCP) (C)

1976-1978
NIH Postdoctoral Fellowship AM 05480-01

1978-1980
Pharmaceutical Manufacturers’ Foundation Award in Clinical
Pharmacology

1981-1986
Established Investigator of American Heart Association

1983
Fellow of the American College of Physicians (FACP)

1986-1991
Burroughs Welcome Clinical Pharmacology Scholar Award

1995
Fellow, Royal College of Physicians of Ireland (FRCP) (I)

2002
Fellow of the Academy of Science of St Louis

2004
National Kidney Foundation of Missouir – Award of Excellence

2005
Fellow of the American Society of Nephrology (FASN)
Fellow of the American Society of Hypertension (FASH)
Fellow of the American Heart Association (FAHA)

2012
Master of the American College of Physicians
American College of Physicians Award for OUtstanding Work in Science as Related to Medicine

2013-2014
Teaching Award of Renal Division

2003-2013
Best Doctors in America

2004-2013
Best Doctors in St. Louis

Clinical Interests

Reno-vascular disease, hypertension and genetic and acquired disorders of sodium, potassium and magnesium handling by the kidney.

Research Interests

My research has focused on identifying the trans-acting factors which bind to a canonical sequence AUUUA present in the COX-2 message and determine which sequences control mRNA stability and which control mRNA translational efficiency using deletion mutagenesis and expression of these constructs in cells.

We have also used this canonical sequence as “bait” to pull down nuclear proteins that bind to this sequence in vitro with high affinity and probe their function in cells using mutagenesis of the active site of these proteins. In addition we have evaluated the mechanisms by which the MAP kinase family of proteins can lead to cyclooxygenase product formation in response to pro-inflammatory cytokines and the potential role of these kinases in the post-translational modification of the trans-acting factors which alters their function.