Since the Division’s founding in 1956, our faculty and staff have made incredible contributions to innovations in nephrology research.
From the publication of the Intact Nephron Hypothesis in 1960 by Dr. Neal Bricker in the American Journal of Medicine to employment of the latest cutting-edge research techniques in our most recent research, our division has been a major force in making great strides in the understanding of kidney disease and health.
Recent Significant Publications
- The single-cell transcriptomic landscape of early human diabetic nephropathy. Wilson P and Humphreys B, et al. PNAS (2019).
- Discovery of novel endoplasmic reticulum calcium stabilizers to rescue ER-stressed podocytes in nephrotic syndrome. Park SJ and Chen Y, et al. Proc Natl Acad Sci (2019).
- Phosphorylated claudin-16 interacts with Trpv5 and regulates transcellular calcium transport in the kidney. Hou J, et al. Proc Natl Acad Sci (2019).
- FOXM1 Drives Proximal Tubule Proliferation During Repair from Acute Ischemic Kidney Injury, Chang-Panesso M and Humphreys B et al. JCI (2019).
- A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys. Blue B and Jain S, et al. Nature Communications 2019.
- Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics. Wu H and Humphreys, et al. Cell Stem Cell (2018).
- Distinct RET and YAP signals regulate the fusion of Wolffian duct and cloaca through a novel reciprocal spatiotemporally controlled apoptosis. Hoshi M and Jain S, et al. JASN (2018).
- Centrosome amplification disrupts renal development and causes cystogenesis. Dionne LK and Mahjoub MR, et al. J Cell Biology (2018).
- A novel Cep120-dependent mechanism inhibits centriole maturation in quiescent cells. Betleja E and Mahjoub MR. eLife (2018).
- Elevated urinary CRELD2 is associated with endoplasmic reticulum stress-mediated kidney disease. Kim Y and Chen Y, et al. JCI Insight (2017).
- A Sall1-NuRD interaction regulates multipotent nephron progenitors and is required for loop of Henle formation. Basta J and Rauchman M et al. Development (2017). (On the cover).
- ILDR1 is important for paracellular water transport and urine concentration mechanism. Gong Y and Hou J. Proc Natl Acad Sci (2017).