Ignacio Portales-Castillo, MD

Ignacio Portales-Castillo, MD

Assistant Professor of Medicine, Division of Nephrology


Patients seen at

Map of location

Barnes-Jewish Hospital

Mailing Address

Division of Nephrology

  • Mailing Address: 660 S. Euclid Ave., CB 8126
    St. Louis, MO 63110


Nephrology Fellowship (2022): Brigham and Women’s Hospital and Massachusetts General Hospital, Boston

Internal Medicine Residency (2019): Rochester General Hospital, Rochester, NY

Medical Degree (2016): Universidad Autonoma de San Luis Potosi; San Luis Potosi, Mexico

Clinical Interests

Bone and mineral disease in patients with chronic kidney disease. Calcium and phosphate disorders.

Research Interests

Parathyroid hormone receptor function. Calcium and phosphate related metabolism.


Biased GPCR signaling by the native parathyroid hormone-related protein 1–141 relative to its N-terminal fragment 1–36. Pena, K; White, A; Savransky, S; Portales-Castillo, I; Alphonse, J; Gardella, T; Sutkeviciute, I; Vilardaga, J. Journal of Biological Chemestry. (2022).

Intravenous sodium thiosulphate for vascular calcification of hemodialysis patients-a systematic review and meta-analysis. Wen, W., Portales-Castillo, I., Seethapathy, R., Krinsky, S., Kroshinsky, D., Kalim, S; Goverman, J; Nazarian, R; Chitalia, V; Malhotra, R; Kramann, R; Malhotra, C; Nigwekar, S. U. Nephrology Dialysis Transplantation. (2022), gfac171. 

Functional properties of two distinct PTH1R mutants associated with either skeletal defects or pseudohypoparathyroidism. Portales‐Castillo, I., Dean, T., Khatri, A., Jüppner, H., & Gardella, T. J. JBMR plus. (2022) 6(6), e10604. 

Prescription Patterns of Osteoporosis Medications in Patients With Advanced CKD: A Retrospective Cohort Study. Kidney Medicine. Portales-Castillo I, Aksu C, Strohbehen I, Zhou S, Yu E, Nigwekar SU. 3.6 (2021): 1112 

PTH, FGF-23, Klotho and Vitamin D as regulators of calcium and phosphorus: Genetics, Epigenetics and Beyond. Portales-Castillo I, and Petra Simic. Frontiers in Endocrinology: 2417. (2022)