Jeannine Basta, PhD

Education

Post-Doctoral Fellowship, Internal Medicine-Nephrology, Saint Louis University, St. Louis, MO

PhD in Biochemistry and Molecular Biology, Saint Louis University, St. Louis, MO 

Bachelor of Science in Chemistry, Lindenwood University, St. Charles, MO

Recognition

2017: Cover photo of Development, Vol 144, Issue 17 http://dev.biologists.org/content/144/17

2015: Selected to attend the Kidney Injury Workshop, Vanderbilt University, Nashville, TN

2005: American Chemical Society Outstanding College Junior Chemistry Award

Research Interests

Renal progenitor cell regulation during embryonic kidney development, chromatin remodeling complexes and their role in kidney development and disease, congenital renal birth defects, acute kidney injury and repair, and therapies to ameliorate kidney fibrosis after injury.

Publications

Disparate levels of beta-catenin activity determine nephron progenitor cell fate. Ramalingam H, Fessler AR, Das A, Valerius MT, Basta J, Robbins L, Brown AC, Oxburgh L, McMahon AP, Rauchman M, Carroll TJ. Developmental Biology. 2018; 440(1):13-21. NIHMSID: NIHMS966482; PMID: 29705331; PMCID: PMC5988999

Amelioration of diet-induced steatohepatitis in mice following combined therapy with ASO-Fsp27 and fenofibrate. Rajamoorthi A, Arias N, Basta J, Lee RG, Baldán Á. Journal of Lipid Research. 2017; 58(11):2127-2138.  PMID: 28874443; PMCID: PMC5665668

A Sall1-NuRD interaction regulates multipotent nephron progenitors and is required for loop of Henle formation. Basta JM, Robbins L, Denner DR, Kolar GR, Rauchman M. Development (Cambridge, England). 2017; 144(17):3080-3094.  PMID: 28760814; PMCID: PMC5611954

Therapeutic silencing of fat-specific protein 27 improves glycemic control in mouse models of obesity and insulin resistance. Langhi C, Arias N, Rajamoorthi A, Basta J, Lee RG, Baldán Á.  Journal of Lipid Research. 2017; 58(1):81-91. PMID: 27884961; PMCID: PMC5234712

A mouse model of Townes-Brocks syndrome expressing a truncated mutant Sall1 protein is protected from acute kidney injury. Hirsch S, El-Achkar T, Robbins L, Basta J, Heitmeier M, Nishinakamura R, Rauchman M.  American Journal of Physiology – Renal Physiology. 2015; 309(10):F852-63. PMID: 26311113The nucleosome remodeling and deacetylase complex in development and disease.

Basta J, Rauchman M.  Translational Research: The Journal of Laboratory and Clinical Medicine. 2015; 165(1):36-47. NIHMSID: NIHMS594971; PMID: 24880148; PMCID: PMC4793962

Sall1 balances self-renewal and differentiation of renal progenitor cells. Basta JM, Robbins L, Kiefer SM, Dorsett D, Rauchman M.  Development (Cambridge, England). 2014; 141(5):1047-58.  PMID: 24550112; PMCID: PMC3929412