Additional Titles

• Associate Editor, Kidney360
• Secretary/Treasurer, Southern Society for Clinical Investigation

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Dr. Gewin in the News:

• Celebrating Faculty Promotions for Drs. Gewin, Herrlich, and Khoury
• Nephrologist Leslie Gewin Receives VA Merit Award Renewal
• Drs. Leslie Gewin and Anuja Java Attend AAMC Women Faculty Leadership Seminar
• New Study by Dr. Leslie Gewin and Colleagues Challenges Long-Held Assumptions of Renal Tubular Responses to Injury
• Dr. Leslie S. Gewin Joins WashU Nephrology Faculty

Education

• Nephrology Fellowship (2009): Vanderbilt University Medical Center, Nashville, TN
• Internal Medicine Residency (2005): Johns Hopkins Medical Institute, Baltimore, MD
• Medical Degree (2002): University of Alabama at Birmingham School of Medicine, Birmingham, AL
• Undergraduate Degree: Princeton University

Board Certifications

• Internal Medicine
• Nephrology

Recognition

VA St. Louis Health Care System Research Service 2025 Investigator of the Year

Clinical Interests

Chronic kidney disease, acute kidney injury, and general nephrology

Research Interests

Mechanisms of chronic kidney disease progression, treatment options to halt kidney disease progression

Publications

• Tubule-specific Compensatory Responses to Cpt1a Deletion in Aged Mice. Funk SD, Kern JT, Viquez OM, Sulvaran-Guel E, Koenitzer JR, Feola KC, Blum JS, Zent R, Humphreys BD, Huen SC, Gewin LG. Kidney360. 2025 May 1;6(5):707-719.
• Assays to Enhance Metabolic Phenotyping in the Kidney. Hammoud S, Kern J, Mukherjee S, Lutkewitte A, Singh P, Newberry K, Finck BN, Gewin LS. Am J Physiol Renal Physiol 2025; Jan 17 online ahead of print.
• Regenerative Role of Lrig1+ Cells in Kidney Repair. Lee Y, Kim KH, Park J, Kang HM, Kim S, Jeong H, Lee B, Lee N, Cho Y, Dae Kim G, Yu S, Yung Gee H, Bok J, Hamilton MS, Gewin L, Aronow BJ, Lim K, Coffey RJ, Nam K. Journal of American Society of Nephrology 2024 Dec 1;35(12):1702-1714.
• Tubular CPT1A Deletion Minimally Affects Aging and Chronic Kidney Injury. Hammoud S, Ivanova A, Osaki Y, Funk S, Yang H, Viquez O, Delgado R, Lu D, Phillips Mignemi M, Tonello J, Colon S, Lantier L, Wasserman D, Humphreys BD, Koenitzer J, Kern J, deCaestecker M, Finkel T, Fogo A, Messias N, Lodhi I, Gewin LS.  JCI Insight 2024 Feb 22;9(6).
• Blocking cell cycle progression through CDK4/6 protects against chronic kidney injury. Osaki Y, Manolopoulou M, Ivanova A, Vartanian N, Phillips Mignemi M, Kern J, Chen J, Yang H, Fogo A, Zhang M, Robinson-Cohen C, Gewin L. JCI Insight 2022 June 22;7(12). (Featured in JCI This Month, July 2022).
• Sugar or Fat? Renal Tubular Metabolism Reviewed in Health and Disease. Gewin LS. Nutrients. 2021 May 9;13(5):1580.
• Erythrocytes A New/Old Target for Hypoxia in Chronic Kidney Disease? Gewin LS. Circ Res. 2020 Jul 17;127(3):376-378.
• Tubular β-catenin and FoxO3 interactions protect in chronic kidney disease. Nlandu-Khodo S, Osaki Y, Scarfe L, Yang H, Phillips-Mignemi M, Tonello J, Saito-Diaz K, Neelisetty S, Ivanova A, Huffstater T, McMahon R, Taketo MM, deCaestecker M, Kasinath B, Harris RC, Lee E, Gewin LS. JCI Insight. 2020 May 21;5(10)
• Wnt/β-Catenin in Acute Kidney Injury and Progression to Chronic Kidney Disease. Huffstater T, Merryman WD, Gewin LS. Semin Nephrol. 2020 Mar;40(2):126-137.
• TGF-β and Diabetic Nephropathy: Lessons Learned Over the Past 20 Years. Gewin LS. Am J Med Sci. 2020 Feb;359(2):70-72.
• Sirtuin 6 and renal injury: another link in the β-catenin chain? Gewin LS. Kidney Int. 2020 Jan;97(1):24-27.
• Proximal tubule ATR regulates DNA repair to prevent maladaptive renal injury responses. Kishi S, Brooks CR, Taguchi K, Ichimura T, Mori Y, Akinfolarin A, Gupta N, Galichon P, Elias BC, Suzuki T, Wang Q, Gewin L, Morizane R, Bonventre JV. J Clin Invest. 2019 Nov 1;129(11):4797-4816.
• Inactivation of Tsc2 in Abcg2 lineage-derived cells drives the appearance of polycystic lesions and fibrosis in the adult kidney. Gewin LS, Summers ME, Harral JW, Gaskill CF, Khodo SN, Neelisetty S, Sullivan TM, Hopp K, Reese JJ, Klemm DJ, Kon V, Ess KC, Shi W, Majka SM. Am J Physiol Renal Physiol. 2019 Nov 1;317(5):F1201-F1210.

See more publications here.