Leslie Gewin, MD

Leslie Gewin, MD

Associate Professor of Medicine, Division of Nephrology

Follow @LeslieGewin on Twitter


Patients seen at

Map of location

John Cochran VA Hospital

Map of location

Barnes-Jewish Hospital

Mailing Address

Division of Nephrology

  • Mailing Address: 660 S. Euclid Ave., CB 8126
    St. Louis, MO 63110

Dr. Gewin in the News:

Dr. Leslie S. Gewin Joins WashU Nephrology Faculty


Nephrology Fellowship (2009): Vanderbilt University Medical Center, Nashville, TN

Internal Medicine Residency (2005): Johns Hopkins Medical Institute, Baltimore, MD

Medical Degree (2002): University of Alabama at Birmingham School of Medicine, Birmingham, AL

Undergraduate Degree: Princeton University

Board Certifications

  • Internal Medicine
  • Nephrology

Clinical Interests

Chronic kidney disease, acute kidney injury, and general nephrology

Research Interests

Mechanisms of chronic kidney disease progression, treatment options to halt kidney disease progression


Sugar or Fat? Renal Tubular Metabolism Reviewed in Health and Disease. Gewin LS. Nutrients. 2021 May 9;13(5):1580.

Erythrocytes A New/Old Target for Hypoxia in Chronic Kidney Disease? Gewin LS. Circ Res. 2020 Jul 17;127(3):376-378.

Tubular β-catenin and FoxO3 interactions protect in chronic kidney disease. Nlandu-Khodo S, Osaki Y, Scarfe L, Yang H, Phillips-Mignemi M, Tonello J, Saito-Diaz K, Neelisetty S, Ivanova A, Huffstater T, McMahon R, Taketo MM, deCaestecker M, Kasinath B, Harris RC, Lee E, Gewin LS. JCI Insight. 2020 May 21;5(10)

Wnt/β-Catenin in Acute Kidney Injury and Progression to Chronic Kidney Disease. Huffstater T, Merryman WD, Gewin LS. Semin Nephrol. 2020 Mar;40(2):126-137.

TGF-β and Diabetic Nephropathy: Lessons Learned Over the Past 20 Years. Gewin LS. Am J Med Sci. 2020 Feb;359(2):70-72.

Sirtuin 6 and renal injury: another link in the β-catenin chain? Gewin LS. Kidney Int. 2020 Jan;97(1):24-27.

Proximal tubule ATR regulates DNA repair to prevent maladaptive renal injury responses. Kishi S, Brooks CR, Taguchi K, Ichimura T, Mori Y, Akinfolarin A, Gupta N, Galichon P, Elias BC, Suzuki T, Wang Q, Gewin L, Morizane R, Bonventre JV. J Clin Invest. 2019 Nov 1;129(11):4797-4816.

Inactivation of Tsc2 in Abcg2 lineage-derived cells drives the appearance of polycystic lesions and fibrosis in the adult kidney. Gewin LS, Summers ME, Harral JW, Gaskill CF, Khodo SN, Neelisetty S, Sullivan TM, Hopp K, Reese JJ, Klemm DJ, Kon V, Ess KC, Shi W, Majka SM. Am J Physiol Renal Physiol. 2019 Nov 1;317(5):F1201-F1210.

See more publications here.