Ying Maggie Chen, MD, PhD, FASN, Associate Professor of Medicine in the Division of Nephrology, has been awarded a National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01 grant totaling $2.969 million for her project, “Activating Autophagy to Treat Uromodulin-Associated Genetic Chronic Kidney Disease.” Autosomal dominant tubulointerstitial kidney disease caused by uromodulin mutations […]
The Center of Regenerative Medicine (CRM) at Washington University has awarded Ying Maggie Chen, MD, PhD, a one-year grant for her proposal entitled “Personalized kidney organoid modeling to develop novel treatment for uromodulin-associated chronic kidney disease.” The CRM is a research collaborative of over 80 faculty members who are dedicated to advancing the science of […]
In their newly-published article in Nature Communications, a multi-center group led by Ying Maggie Chen, MD, PhD, WashU Division of Nephrology, describes previously unknown mechanisms of action of mesencephalic astrocyte-derived neurotrophic factor (MANF) and its therapeutic function, with regards to kidney disease. MANF is a secreted endoplasmic reticulum (ER) protein that possesses cytoprotective properties. Their […]
Thanks to a new study headed by Ying Maggie Chen, MD, PhD, it may soon be possible to diagnose certain human kidney diseases in their earliest stages of development using a noninvasive biomarker of endoplasmic reticulum (ER) stress. The study, Elevated Urinary CRELD2 is Associated with Endoplasmic Reticulum Stress-mediated Kidney Disease, was published online in […]