Sanjay Jain, MD, PhD

Associate Professor of Medicine, Division of Nephrology

Additional Titles

Related Links

Mailing Address

Division of Nephrology

  • Mailing Address: 660 S. Euclid Ave., CB 8126
    St. Louis, MO 63110

Education

  • AB, Genetics: University of California-Berkeley, Berkeley, CA (1990)
  • MD: Northwestern University, Chicago, IL (1999)
  • PhD, Integrated Biology: Northwestern University, Chicago, IL (1999)
  • Residency, Anatomic Pathology: Washington University School of Medicine, St. Louis, MO (2001)
  • Postdoctoral Fellow, Cancer, Neurodevelopment: Washington University School of Medicine, St. Louis, MO (2004)

Recognition

2018-2020
Steering Committee, Human Biomolecular Atlas Project (HuBMAP) (NIH – common fund)

2017-Present
Executive Committee, Kidney Precision Medicine Project (KPMP, NIH/NIDDK)
– Chair, Quality control Tissue Interrogation Sites (KPMP)
– Co-Chair, Pathology and Molecular Integration Committee (KPMP)

2017-2019
Chair, NIDDK/KMBD study section, Center for Scientific Review, NIH

2017-2019
Steering Committee, Kidney Precision Medicine Project (NIH/NIDDK)

2017-2018
American Society of Nephrology, Program Committee

2017
First Prize, British Medical Association book award in the Pathology category for Diagnostic Pathology: Kidney Diseases, 2nd edition, Editor Robert Colvin and Anthony Chang, Publisher- Elsevier Inc. 2015. ISBN 978-0-323-37707-2; contributed 9 chapters

2016-present
Steering Committee, ReBuilding a Kidney (RBK) project (NIH/NIDDK)

2014-2019
Standing member, KMBD study section, Center for Scientific Review, NIH

2014
Study Section Member, Center for Scientific Review, KMBD, NIH

2013-2016
Steering and Executive Committee, Genitourinary Development Molecular Anatomy Project (GUDMAP) (NIDDK)

2013
ASCI Inductee, American Society of Clinical Investigators
Steering and Executive Committee, GUDMAP, NIH-NIDDK

2012
Editorial Board Member, Journal of Biological Chemistry

2009
CDI Investigator Award, Children’s Discovery Institute

2008-2010
Board of Directors, Chair Communications and Website Committee, Renal Pathology Society

2008
Board of Directors, Chair, communications and publications committee, Renal Pathology Society

2007
Pirani Award, Renal Pathology Society
KUFA-RPS research award, Kidney and Urology Foundation

2004
K08 Award, NIH-NICHD

2003
NIH-LRP award (3 competitive renewals), NIH

2001
NRSA training grant fellowship (T32), Washington University School of Medicine, St. Louis

1995
Graduate Student Fellowship Award, International Society of Toxicology

1995
Molecular Biology Specialty Section Award, First Prize, International Society of Toxicology

1991
MSTP Fellowship, Northwestern University

1990
Graduation with Distinction in General Scholarship
High Honors for Undergraduate Thesis
Departmental Citation for Outstanding Accomplishment in Genetics, University of California, Berkeley, CA

1984
Open Merit Scholarship, Indian Ministry of Education, India

Research Interests

Research Interests:  Kidney development, ureter development, CAKUT, AKI, genomics, neurodevelopment, GDNF, RET, branching morphogenesis, genetics, biobanking, translational research, biomarkers, regeneration, stem cells, bladder regeneration, bladder pain

Funding: NIH/NIDDK, March of Dimes, GUDMAP consortium, BJIH

Research Description
The major goal of my laboratory is to decipher molecular and genetic mechanisms underlying development and diseases of the kidneys and lower urinary tract. Our main hypothesis is that developmentally important genes play a role in congenital malformations, repair and regeneration of organs in acute and chronic diseases, and cancer. To this end we use disease model systems and “omic” technologies and integrate basic science and clinical research. Below are the major ongoing projects.

Investigations of early urogenital development and patterning. Glial cell line-derived neurotrophic factor (GDNF)-RET receptor tyrosine kinase signaling is required for kidney formation (ureteric bud induction), ureter maturation and branching morphogenesis. These events rely on reciprocal interactions between the RET expressing ureteric bud epithelial cells that are also the precursors for the collecting ducts, and the GDNF expressing metanephric mesenchyme. We are using GDNF-RET signaling system as a paradigm to decipher the cellular events (proliferation, cell movements, cell death and cell interactions) and mechanisms during early development of the Wolffian duct, ureteric budding and branching, insertion of ureter into the cloaca and innervation of the urinary tract. Ongoing studies include using novel genetically engineered mice, whole mount 4-D live time-lapse microscopy, population and single cells analysis of defined cell-types to determine the fate of RET-expressing cells in the genitourinary tract, role of RET associated pathways in acute injury and regeneration, and genetic abnormalities in CAKUT patients. These studies will provide insights into pathogenesis, diagnosis and treatment of CAKUT and fundamental knowledge to make new kidneys and ureters.

Discovery of genetic variants associated with kidney disease and their mechanisms of action. In collaboration with pathologists, pediatric nephrologists and urologists we have enrolled several hundred patients from the Midwest region with a spectrum of kidney diseases and collected their serum, plasma, cells, urine and DNA. The goal is to use these resources to discover new biomarkers associated with diagnoses and prognosis, and gene variants associated with disease. Our major focus is currently on CAKUT and glomerular diseases using whole exome or custom targeted exome sequencing and then using model systems in vitro and in vivo to understand causative mechanisms. These studies will identify new causes of CAKUT, and provide novel insights into how developmentally important genes cause these defects, lead to CKD and renal failure.

Mechanisms of acute injury and regeneration. We have implemented various models of acute injury to the kidneys (rhabdomyolysis, ischemia-reperfusion injury, ureteral obstruction) and to the bladder (UTI, chemical toxicity). We are using these in different scenarios to determine how interactions between development genes and environment impact repair, regeneration and function. In the lower urinary tract we are particularly interested in interactions between the peripheral nervous system and epithelial homoeostasis.

Publications (Research Articles and Book Chapters):

Research Articles

Blue B. Lake, Song Chen Masato Hoshi, Nongluk Plongthongkum, Diane Salamon, Amanda Knoten, Anitha Vijayan, Ramakrishna Venkatesh, Eric H. Kim, Derek Gao, Joseph Gaut, Kun Zhang, Sanjay Jain. A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys Nature Communications 2019 Jun 27;10(1):2832. PMID: 31249312 PMCID: PMC6597610

Hongtao Zhang, Mazdak Bagherie-Lachidan, Caroline Badouel, Leonie Enderle, Philippos Peidis, Rod Bremner, Sanjay Jain, Helen McNeill. FAT4 fine-tunes kidney development by regulating RET signaling. Dev Cell, 2019 Mar 25;48(6):780-792. PMID: 30853441

Brendon Lutnick, Brandon Ginley, Darshana Govind, Sean D. McGarry, Peter S.       LaViolette, Rabi Yacoub, Sanjay Jain, John E. Tomaszewski, Kuang-Yu Jen and Pinaki Sarder. An integrated iterative annotation technique for easing neural network training in medical image Analysis. Nature Machine Intelligence, 2019. (1):112-119.  PMID: 31187088.  PMCID: PMC6557463

Seifert ME, Gaut JP, Guo B, Jain S, Malone AF, Geraghty F, Della Manna D, Yang ES, Yi N, Brennan DC, Mannon RB.  WNT pathway signaling is associated with microvascular injury and predicts kidney transplant failure. Am J Transplant. 2019 Mar 27. PMID: 30916889 DOI: 10.1111/ajt.15372

S. Jain and Chen, F. Developmental pathology of congenital kidney and urinary tract anomalies. Clin Kidney J, 2018. 12(3):382-399. PMID: 31198539 PMCID: PMC6543978 DOI: 10.1093/ckj/sfy112

Lai Kuan Dionne, Kyuhwan Shim, Masato Hoshi, Tao Cheng, Jinzhi Wang, Veronique Marthiens, Amanda Knoten, Renata Basto, Sanjay Jain, and Moe R. Mahjoub.  Centrosome Amplification Disrupts Renal Development and Causes Cystic Dysplasia. Journal of Cell Biology 2018 217(7):2485-2501. PMID:29895697. PMCID:PMC6028550

Huang KL, Mashl RJ, Wu Y, Ritter DI, Wang J, Oh C, Paczkowska M, Reynolds S, Wyczalkowski MA, Oak N, Scott AD, Krassowski M, Cherniack AD, Houlahan KE, Jayasinghe R, Wang LB, Zhou DC, Liu D, Cao S, Kim YW, Koire A, McMichael JF, Hucthagowder V, Kim TB, Hahn A, Wang C, McLellan MD, Al-Mulla F, Johnson KJ; Cancer Genome Atlas Research Network., Lichtarge O, Boutros PC, Raphael B, Lazar AJ, Zhang W, Wendl MC, Govindan R, Jain S, Wheeler D, Kulkarni S, Dipersio JF, Reimand J, Meric-Bernstam F, Chen K, Shmulevich I, Plon SE, Chen F, Ding L. Pathogenic Germline Variants in 10,389 Adult Cancers. Cell. 2018 Apr 5;173(2):355-370.e14. doi: 10.1016/j.cell.2018.03.039. PMID: 29625052.

Kudose S, Hoshi M, Jain S, Gaut JP. Renal Histopathologic Findings Associated With Severity of Clinical Acute Kidney Injury. Am J Surg Pathol. 2018 Mar 13. doi: 10.1097/PAS.0000000000001028. [Epub ahead of print] PubMed PMID: 29537990.

Hoshi M, Reginensi A, Joens M, Fitzpatrick J, McNeill H, Jain S.  Distinct RET and YAP signals regulate the fusion of Wolffian duct and cloaca through a novel reciprocal spatiotemporally controlled apoptosis. JASN, 2018. 29(3):775-783. PMID: 29326158. PMCID: PMC5827592.

Simon O, Yacoub R, Jain S, Tomaszewski JE, Sarder P. Multi-radial LBP Features as a Tool for Rapid Glomerular Detection and Assessment in Whole Slide Histopathology Images. Sci Rep. 2018 Feb 1;8(1):2032. doi: 10.1038/s41598-018-20453-7. PubMed PMID: 29391542; PubMed Central PMCID: PMC5795004.

Kim AH, Chung JJ, Akilesh S, Koziell A, Jain S, Hodgin JB, Miller MJ, Stappenbeck TS, Miner JH, Shaw AS. B cell derived IL-4 acts on podocytes to induce proteinuria and podocyte foot process effacement. JCI Insight. 2017;2(21). Kim AH, Chung JJ, Akilesh S, Koziell A, Jain S, Hodgin JB, Miller MJ, Stappenbeck TS, Miner JH, Shaw AS. B cell derived IL-4 acts on podocytes to induce proteinuria and podocyte foot process effacement. JCI Insight. 2017;2(21). PMID: 29093269 PMCID: PMC5752294.

Suleiman HY, Roth R, Jain S, Heuser JE, Shaw AS, Miner JH. Injury-induced actin cytoskeleton reorganization in podocytes revealed by super-resolution microscopy. JCI Insight. 2017;2(16). doi: 10.1172/jci.insight.94137. PMID:28814668.

Jeremy K. Moore, Junjie Chen, Hua Pan, Joseph P. Gaut,  Sanjay Jain,  Samuel A. Wickline.  Quantification of vascular damage in acute kidney injury with fluorine magnetic resonance imaging and spectroscopy.  Magnetic Resonance in Medicine. 2017. 79;3144-3153. PMID: 29148253.

Andrew J. Shepherd, Aaron D. Mickle, Bryan A. Copits, Páll Karlsson, Suraj Kadunganattil, Judith P. Golden, Satya M. Tadinada, Madison Mack, Simon Haroutounian,  Annette D. de Kloet, Vijay K. Samineni, Manouela V. Valtcheva, Sanjay Jain, Pradipta R. Ray, Yuriy M. Usachev, Gregory Dussor, Justin L. Grobe, Brian S. Kim, Eric G. Krause, Theodore J. Price, Robert W. Gereau IV, and Durga P. Mohapatra.  Angiotensin II triggers peripheral macrophage-to-sensory neuron redox crosstalk to elicit pain. J. Neurosci. 2018 38 (32) 7032-7057. PMID: 29976627.

Gaut JP, Jain S, Pfeifer JD, Vigh-Conrad KA, Corliss M, Sharma MK, Heusel JW, Cottrell CE.  Routine Use of Clinical Exome-Based Next Generation Sequencing for Evaluation of Patients with Thrombotic Microangiopathies. Modern Pathology. 2017 Jul 28. doi: 10.1038/modpathol.2017.90. [Epub ahead of print]. PMID:28752844.

Oxburgh L, Carroll TJ, Cleaver O, Gossett DR, Hoshizaki DK, Hubbell JA, Humphreys BD, Jain S, Jensen J, Kaplan DL, Kesselman C, Ketchum CJ, Little MH, McMahon AP, Shankland SJ, Spence JR, Valerius MT, Wertheim JA, Wessely O, Zheng Y, Drummond IA. (Re)Building a Kidney. J J Am Soc Nephrol. 2017. doi: 10.1681/asn.2016101077. PMID:28096308. PMCID: “In Process”

Wilfert, A. B., K. R. Chao, M. Kaushal, S. Jain, S. Zollner, D. R. Adams and D. F. Conrad. Genome-wide significance testing of variation from single case exomes. Nat Genet advance online publication. 2016. Dec; 48(12):1455-1461. PMID:27776118.  PMCID: PMC5127779. doi: 10.1038/ng. 3697

Kramann R, Goettsch C, Wongboonsin J, Iwata H, Schneider RK, Kuppe C, Kaesler N, Chang-Panesso M, Machado FG, Gratwohl S, Madhurima K, Hutcheson JD, Jain S, Aikawa E, Humphreys BD. Adventitial MSC-like cells are progenitors of vascular smooth muscle cells and drive vascular calcification in chronic kidney disease. Cell Stem Cell. 2016. Nov 3;19(5):628-642. doi: 10.1016/j.stem.2016.08.001. PMID: 27618218 

Emily Ma, Joel Vetter, Laura Bliss, H. Henry Lai, Indira U. Mysorekar, Sanjay Jain.  A multiplexed analysis approach identifies new association of inflammatory proteins in patients with overactive bladder.  Am J Physiol Gastrointest Renal Physiol. 2016:Jul 1;311(1):F28-34. PMID: 27029431. PMCID: PMC4967156

Lai HH, Vetter J, Jain S, Andriole GL. Systemic Non-Urologic Symptoms in Patients with Overactive Bladder. J Urol. 2016 Mar 17. pii: S0022-5347(16)03460-1. doi: 10.1016/j.juro. 2016. Jul 1;311(1):F28-34. PMID: 26997309. PMCID: “In Process”

Yu, Haiyang, Artomov, Mykyta, Brähler, Sebastian, Stander, M. Christine, 

Shamsan, Ghaidan, Sampson, Matthew G., White, J. Michael, Kretzler, Matthias,

Miner, Jeffrey H., Jain, Sanjay, Winkler, Cheryl A., Mitra, Robi D., Kopp, Jeffrey B., Daly, Mark J. and Shaw, Andrey S.  A role for genetic susceptibility in sporadic focal segmental glomerulosclerosis. The Journal of Clinical Investigation 2016.126:1067-1078. PMID: 26927868. PMCID: PMC4811140

Mwangi SM, Peng S, Nezami BG, Thorn N, Farris AB 3rd, Jain S, Laroui H, Merlin D, Anania FA, Srinivasan S.Glial Cell Line-Derived Neurotrophic Factor Protects Against High Fat Diet-Induced Hepatic Steatosis by Suppressing Hepatic PPAR-gamma Expression. Am J Physiol Gastrointest Liver Physiol. 2016. Jan 15;310(2):G103-16. PMID:26564715. PMCID: PMC4719063 

Hoshi M, Wang J, Jain S and Mahjoub MR.  Imaging centrosomes and cilia in the mouse kidney.  Methods Cell Biol. 2015;127:1-17

Antoine Reginensi, Masato Hoshi, Sami Kamel Boualia, Maxime Bouchard, Sanjay Jain, and Helen McNeill.  Yap and Taz are Required for Ret-Dependent Urinary Tract Morphogenesis.  Development, 2015.142(15):2696-2703.  PMID: 26243870. PMCID: PMC4529030

Vijayan A, Li T, Dusso A, Jain S and Coyne D. Relationship of 1,25 dihydroxy Vitamin D Levels to Clinical Outcomes in Critically Ill Patients with Acute Kidney Injury. Nephrology & Therapeutics, 2015, 5(1):1000190 (open access).

Anyaegbu E, Shaw A, Hruska K, and Jain S.  Clinical Phenotype of APOL-1 Nephropathy in Young Relatives of Patients with End Stage Renal Disease.  Pediatric Nephrology, 2015. Jun;30(6):983-9 PMID: 25530085. PMCID: PMC4406792

Lai HH, Vetter J, Jain S, Gereau RW 4th, Andriole GL.. The Overlap and Distinction of Self-Reported Symptoms between Interstitial Cystitis/Bladder Pain Syndrome and Overactive Bladder: A Questionnaire Based Analysis.  J. Urology, 2014. 192 (6):1679-1686.  PMID: 24907443

Sanjay Jain, MD, PhD, Michiel J. Noordam, PhD, Masato Hoshi, MD, PhD, Francesco L. Vallania,  PhD, Donald F. Conrad, PhD. Validating single cell genomics for the study of renal development.  Kidney International, 2014. Apr 23. doi: 10.1038/ki.2014.104. [Epub ahead of print] PMID:  24759149.  PMCID: PMC420772

Joseph P Gaut, Dan L Crimmins, Matt F Ohlendorf, Christina M Lockwood, Terry A Griest, Nancy A Brada, Masato Hoshi, Bryan Sato, Richard S Hotchkiss, Sanjay Jain, and Jack H Ladenson. Development of an Immunoassay for the Kidney Specific Protein myo-Inositol Oxygenase, a Potential Biomarker of Acute Kidney Injury. Clin Chem, 2014. May;60(5):747-57.PMID: 24486646

Gaut JP, Hoshi M, Jain S, Liapis H. Claudin 1 and nephrin label cellular crescents in diabetic glomerulosclerosis.  Human Pathology. 2014, 45 (3):628-35.  PMID: 24529330.

Golden, J. P., DeMaro III, J.A , Knoten, A., Hoshi, M., Pehek, E., Johnson, Jr., E.M. Gereau IV, R.W., Jain, S.  Dopamine-dependent compensation maintains motor behavior in mice with developmental ablation of dopaminergic neurons. Journal of Neuroscience.  2013. Oct 23;33(43)17095-107.  PMID: 24155314.  PMCID: PMC3839561

Rajshekhar Chatterjee, Mary Hoffman, Paul Cliften, Surya Seshan,Helen Liapis, Sanjay Jain.  Targeted candidate exome capture in conjunction with multiindexing and next-generation sequencing identifies known and novel deleterious variants in Alport’s and renal malformations. PloS One, 2013. 8(10):e76369. PMID: 24130771

Liapis H, Jain S.  The Interface of Genetics with Pathology in Alport Nephritis. J Am Soc Nephrol. 2013. Dec;24(12):1925-7. PMID:24071003.

Davis TK, Hoshi M, and Jain S. To Bud or Not to Bud: The Ret Perspective. Pediatric Nephrology 2013. PMID: 24022366

Davis TK, Hoshi M, and Jain S.  Stage specific requirement of Gfrα1 in the ureteric epithelium during kidney development. Mech Dev. 2013 Mar 28. doi:pii: S0925-4773(13)00025-7. 10.1016/j.mod.2013.03.001. [Epub ahead of print] PMID:23542432.  “PMCID-In Process” NIHMS 462467.

Navin ViswakarmaJain, Yuzhi Jia , Liang Bai, Aurore Vluggens , Qian Gao, Bingliang Lin, Xiaohong Zhang, Parimal Misra, Ajay Rana, Sanjay Jain, Frank J. Gonzalez , Yi-Jun Zhu, Bayar Thimmapaya, and Janardan K. Reddy.  Med1 Subunit of the Mediator Complex Induces Liver Cell Proliferation and is Phosphorylated by AMPK. JBC. 2013. 238 (39): 27898-911.  PMID:23943624. PMCID:PMC3784705

Krentz AD, Murphy MW, Zhang T, Sarver AL, Jain S, Griswold MD, Bardwell VJ, Zarkower D. Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line. Dev Biol. 2013 May 1;377(1):67-78. doi: 10.1016/j.ydbio.2013.02.014. Epub 2013 Mar 6. PMCID: PMC3630265

Hoshi M, Batourina E, Mendelsohn, C and Jain S.  Novel regulatory mechanisms of early upper and lower urinary tract patterning by RetY1015 docking tyrosine in mice. Development 2012: Jul;139(13):2405-15.  PMID: 22627285. PMCID: PMC336747

Featured in Research Highlights by Susan J. Allison-Nature Reviews Nephrology 8, 432 (August 2012).

Chatterjee R, Ramos E, Hmiel P, Beck A, Hruska K, Coplen D, Liapis H, Mitra R, Austin P, Druley T and Jain S.  Traditional and targeted exome sequencing reveals common, rare and novel functional deleterious variants in RET signaling complex in a cohort of living US patients with urinary tract malformations. ­Human Genetics 2012: Nov;131(11):1725-38.  PMID: 22729463.  PMCID: PMC3551468.

Jain S, De Petris L, Hoshi M, Akilesh S, Chatterjee R and Liapis H. Expression profiles of podocytes exposed to high glucose reveal new insights into early diabetic glomerulopathy.  Lab. Invest. 2011: 91:488-498.  (cover illustration) (corresponding author).  PMID:21102505. PMCID: PMC3068212

Langsdorf A, Schumacher V, Shi X, Tran T, Zaia J, Jain S, Taglienti M, Kreidberg JA, Fine A, Ai X. WT1-regulated expression of Sulfs is required for GDNF bioavailability in the spermatogonial stem cell niche.  Glycobiology 2011: 21(2):152-61.  PMID:20855470.  PMC Journal – In Press

Jain S*, Knoten A, Hoshi M, Wang H, Vohra B, Heukeroth R and Milbrandt J. Organotypic specificity of RET-docking tyrosine residues in pathogenesis of neurocristopathies and renal malformations in mice. J Clin Invest 2010: 120(3): 778-790. *Corresponding Author. Featured in highlights of the month. PMID: 20160347. PMCID: PMC2827965. 

Tripathi P, Guo Q, Wang Y, Coussens M, Liapis H, Jain S, Kuehn MR, Capecchi MR and Chen F.  Midline signaling regulates kidney positioning but not nephrogenesis through Shh.  Dev Biol. 2010 Apr 15;340(2):518-27.  PMID:20152829.  PMCID: PMC2854326.

Langsdorf A, Radzikinas K, Kroten A, Jain S and Ai X.  Neural Crest Cell Origin and Signals for Intrinsic Neurogenesis in the Mammalian Respiratory Tract.  Am J Respir Cell Mol Biol. 2011: 44(3):293-301. PMID:20139349. PMC Journal – In Process

Golden J, Hoshi M, Nassar M, Enomoto H, Wood J, Milbrandt J, Gereau R, Johnson EMJr, and Jain S.  RET Signaling is Required for Survival and Normal Function of Non-Peptidergic Nociceptors. J. Neurosci 2010: 30(11):3983-94. PMID: 20237269.  PMCID: PMC2850282

Jain S. The many faces of RET dysfunction in kidney. Organogenesis 2009 5(4):1-14. PMCID : PMC2878746

Zhang B, Chang J, Fu M, Huang J, Kashyap R, Salavaggione E, Jain S, Kulkarni S, Deardorff MA, Uzielli ML, Dorsett D, Beebe DC, Jay PY, Heuckeroth RO, Krantz I, Milbrandt J.  Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies. PLoS One. 2009;4(5):e5232. PMCID: PMC2672303

Rozen, E.J., Schmidt, H., Dolcet, X., Basson, M., Jain, S., and Encinas, M.  Loss of Sprouty1 rescues renal agenesis in Ret knockin mice lacking tyrosine 1062.  JASN, 2009; 20(2):255-259. 

Encinas, M., Rozen, E. J., Dolcet, X., Jain, S., Comella, J. X., Milbrandt, J., Johnson, E. M.  Analysis of Ret knockin mice reveals a critical role for IKKs, but not PI 3-K, in neurotrophic factor-induced survival of sympathetic neurons. Cell Death Differ. 2008; 15(9):1510-21. PMCID: PMC2646785

Brantley, M., Jain, S., Barr, E., Johnson, E., and Milbrandt, J.  Neurturin-mediated Ret activation is required for retinal function.  J. Neurosci. 2008; 28(15): 4123. (featured in this week in neuroscience). PMCID:PMC2646785

Wahrle SE, Jiang H, Parsadanian M, Kim J, Li A, Knoten A, Jain S, Hirsch-Reinshagen V, Wellington CL, Bales KR, Paul SM, Holtzman DM. Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.  J Clin Invest. 2008 February 1; 118(2): 671–682.

Zhang, B., Jain, S., Song, H., Fu, M., Heuckeroth, R.O., Erlich, J.M., Jay, P.Y., and Milbrandt, J.D.  Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome. Development, 2007; 134:3191-3201.

Uesaka, T., Jain, S., Yonemura, S., Uchiyama, Y., Milbrandt, J., and Enomoto, H.  Conditional ablation of GFRα1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung disease phenotype. Development, 2007; 134(11):2171-2181.

Jain, S., Suarez, A.A., McGuire, J., and Liapis, H.  Expression profiles of Renal Dysplasia Reveal New Insights in Renal Development and Disease.  Pediatric Nephrology. 2007; 22(7):962-974.

Vohra, B.P., Planer, W., Armon, J., Fu, M., Jain, S., Heuckeroth, R.  Reduced endothelin converting enzyme-1 and endothelin-3 mRNA in the developing bowel of male mice may increase expressivity and penetrance of Hirschsprung disease-like distal intestinal aganglionosis.  Developmental Dynamics, 2007(236):106-117.

Jain S., Golden, J., Wozniak, D., Pehek, E.,  Johnson, E., and Milbrandt, J.  RET is dispensable for maintenance and function of midbrain dopaminergic neurons. J. Neurosci. 2006; 26(43):11230-8. (corresponding author) (editor’s choice).

Jain S, Encinas, M, Johnson, E and Milbrandt J. Critical and distinct roles for key RET tyrosine docking sites in renal development.  Genes & Development. 2006 20:321-333. (*co-corresponding author).

Naughton C, Jain S*, Strickland A, Gupta A, Milbrandt J. GDNF-mediated RET signaling regulates spermatogonial stem cell fate. Biology of Reproduction. 2006; 74(2):314-21. (* co-first, and co-corresponding author) (cover illustration).

Ippolito, J. E., Xu, J., Jain, S., Moulder, K., Mennerick, S., Crowley, J. R., Townsend, R. R., and Gordon, J. I. An integrated functional genomics and metabolomics approach for defining poor prognosis in human neuroendocrine cancers. PNAS 2005; 102:9901-9906.

Jain S, Naughton CK, Yang M, Strickland A, Vij K, Encinas M, Golden J, Gupta A, Heuckeroth R, Johnson Jr EM, Milbrandt J.  Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis. Development. 2004;131:5503-5513

Jain S, Watson M, DeBenedetti  M,  Hiraki Y, Moley J, Milbrandt J.  Expression profiles provide insights into early malignant potential and skeletal abnormalities in Multiple Endocrine Neoplasia type 2B syndrome tumors. Cancer Research 2004 June1; 64(11):3907-13

Cook WS, Jain S, Jia Y, Cao WQ, Yeldandi AV, Reddy JK, Rao MS. Peroxisome proliferator-activated receptor alpha-responsive genes induced in the newborn but not prenatal liver of peroxisomal fatty acyl-CoA oxidase null mice. Exp Cell Res. 2001 Aug 1;268(1):70-6.

Kan L, Jain S*, Cook W, Cao WQ, Usuda N, Yeldandi AV, Rao MS, Kanwar YS, Reddy JK.Cloning and expression of the mouse deoxyuridine triphosphate nucleotidohydrolase gene: differs from the rat enzyme in that it lacks nuclear receptor interacting LXXLL motif. Gene Expr. 1999;8(4):231-46 (*co-first author) (cover illustration).

Zhu Y, Qi C, Jain S, Le Beau MM, Espinosa R 3rd, Atkins GB, Lazar MA, Yeldandi AV, Rao MS, Reddy JK. Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer. Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10848-53

Jain S, Maltepe E, Lu MM, Simon C, Bradfield CA. Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse.
Mech Dev. 1998 Apr;73(1):117-23

Jain S,  Pullikuri S, Zhu Y, Qi C, Kanwar YS, Yeldandi AV, Rao MS, Reddy JK. Differential expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) and its coactivators steroid receptor coactivator-1 and PPAR-binding protein PBP in the brown fat, urinary bladder, colon, and breast of the mouse. Am J Pathol. 1998 Aug;153(2):349-54. (cover illustration)

Carver LA, LaPres JJ, Jain S, Dunham EE, Bradfield CA. Characterization of the Ah receptor-associated protein, ARA9. J Biol Chem. 1998 Dec 11; 273(50):33580-7.

Hogenesch JB, Gu YZ, Jain S, Bradfield CA. The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc Natl Acad Sci U S A. 1998 May 12;95(10):5474-9.

Luo G, Gu YZ, Jain S, Chan WK, Carr KM, Hogenesch JB, Bradfield CA. Molecular characterization of the murine Hif-1 alpha locus. Gene Expr. 1997;6(5):287-99.

Zhu Y, Qi C, Jain S, Rao MS, Reddy JK.Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. J Biol Chem. 1997 Oct 10;272(41):25500-6

Jain, S., Dolwick, K.M,, Schmidt, J.S., Bradfield, C.A. Potent Transactivation Domains of the Ah Receptor and the Ah Receptor Nuclear Translocator Map to their Carboxyl termini, J. Biol. Chem., 1994 269: 31518-31524.

Chan, W.C., Chu, R., Jain, S., Reddy, J.K., Bradfield, C.A. Baculovirus expression of the Ah Receptor and the Ah Receptor Nuclear Translocator, J. Biol. Chem., 1994 269 (42): 26464-26471.

Hayashi, S., Jain, S., Chu, R., Alvares, K., Xu, Bin., Erfurth, F., Usuda, N., Rao, M.S., Reddy, S.K., Noguchi, T., Reddy, J.K., Yeldandi, A.V. Amphibian Allantoinase: Molecular cloning, tissue distribution, and functional expression, J. Biol. Chem., 1994 269: 12269-12276.

Syvaoja, J., Soumensaari, S., Nishida, C., Goldsmith, J.S., Chui, G.S.J., Jain, S., Linn, S. DNA polymerases α, δ and ε: Three distinct enzymes from HeLa cells, Proc. Natl. Acad. Sc., USA, 1990 87: 6664-6668.

Book Chapters

Jain S. (2014) Kidney Development and Related Anomalies. In: Linda M. McManus, Richard N. Mitchell, editors. Pathobiology of Human Disease. San Diego: Elsevier; 2014. p. 2701-2715. 

Following 9 chapters in Diagnostic Pathology: Kidney Diseases, 3rd edition, Editor Robert Colvin and Anthony Chang, Publisher- Elsevier Inc. 2019. IISBN 978-0-323-66108-9

*First Prize, British Medical Association book award in the Pathology category (2015 2nd edition)

1.Jain S. Normal Kidney Development, 36-45.

2.Jain S. Overview and Classification of Genetic Diseases of the Glomerulus, 350-351

3.Jain S. Overview of Congenital Anomalies of the Kidney and Urinary Tract, 828-831

4.Jain S. Dysplasia, Hypoplasia and Agenesis, 832-837

5.Jain S. Ectopia, Malrotation, Duplication, Fusion, Supernumerary Kidney, 840-843

6.Jain S. Introduction to Impediments to Urine Flow, 914-917

7.Jain S. Reflux Nephropathy, 918-921 

8.Jain S. Obstructive Nephropathy, 922-925 

9.Jain S. Diagnostic Genetics of Kidney Diseases, 1098-1101

PhD Thesis (1999): Characterization of a subset of bHLH-PAS superfamily of transcription factors.  (Ph.D., Northwestern University).