Tag: myofibroblasts

Repurposing Drugs May Help Fast-track Clinical Trials Aimed at Slowing Alport Syndrome Progression

The Alport Syndrome Foundation awarded Dr. Benjamin Humphreys, Joseph Friedman Professor of Renal Diseases in Medicine and Chief, Division of Nephrology, a two-year, $125,000 grant for his proposal “Tubulointerstitial Profiling for Alport Syndrome Target Identification.” Alport Syndrome results from damage caused to podocytes, cells that help form the filtration barrier within the glomerulus.  Damage to […]

Study Details Origin of Myofibroblasts Responsible for Kidney Fibrosis

The results of an international collaboration of researchers including Dr. Benjamin Humphreys, Division of Nephrology at Washington University, and Dr. Rafael Kramann, Division of Nephrology and Clinical Immunology at RWTH Aachen University in Germany, published in the May issue of JCI insight, settles the years-old controversy of the origin of scar-forming macrophages in the kidney. […]

Meis1 in Kidney Aging and Injury – Unexpected Findings

A new study headed by Dr. Monica Chang-Panesso, MD, Nephrology, revealed unexpected findings in an investigation of Meis1, a transcription factor that is required for mammalian development. Meis1 is a known marker of interstitial stroma in the developing kidney. Defects in kidney development are seen in Meis1 mutant embryos. The homeobox protein plays an important […]

ASN Kidney Week – WU Nephrology Lectures, Moderators, Posters and Podcast

Program Director’s Meeting – Hot Topics from the Training Program Exchange > Wednesday, November 16 > Moderator > Hot Topics from the Training Program Exchange > 5:35 p.m. > BR C/D     Critical Care Nephrology: Using Prolonged Intermittent RRT in the ICU: How Do I Prescribe It, and When Do I Use It? Wednesday, November 16 […]