Grant

Monica Chang-Panesso Awarded RO1 Grant to Study Cellular Senescence and AKI-to-CKD Transition

Monica Chang-Panesso

WashU Nephrology proudly congratulates Monica Chang-Panesso, MD, Assistant Professor of Medicine, on receiving her first NIH RO1 grant.  The four-year, $1.5 million award will support her research project: Cellular Senescence and the Acute Kidney Injury (AKI) to Chronic Kidney Disease (CKD) transition.

Building on her prior studies, Chang-Panesso aims to identify cellular senescence as a key driver of failed renal repair and to uncover the molecular mechanisms underlying this process, ultimately defining new targets for therapeutic intervention.

Since joining WashU Nephrology in 2015, Chang-Panesso has demonstrated a commitment to bench research alongside her clinical practice.  Her work explores the molecular mechanisms of kidney repair after acute injury, with a particular focus on how aging disrupts recovery and contributes to chronic disease progression. 

Her recent accomplishments include a KidneyCure Grant (2025), the 2023 Southern Society for Clinical Investigation (SSCI) Research Scholar Award, the inaugural Roger M. Perlmutter Career Development Professorship (2021), and a five-year K08 Mentored Clinical Scientist Research Career Development Award (2020) to study tubular senescence and proliferative capacity of the aging kidney. 


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