Additional Titles

• Professor of Medicine

Related Links

• The Humphreys Laboratory

Location

Patients seen at

Mailing Address

Dr. Humphreys in the News:

• Benjamin Humphreys Joins Journal of Clinical Investigation Editorial Board
• National Kidney Foundation Award of Excellence Presented to Benjamin Humphreys
• WashU Nephrology Chief, Ben Humphreys, and Alumnus David Basile speak at The University of Alabama at Birmingham Annual Renal Symposium 2023.
• WashU Nephrologists Marcos Rothstein and Benjamin Humphreys Work to Increase the Pool of Transplantable Kidneys
• Benjamin Humphreys Elected Vice-President of ASCI
• Benjamin Humphreys Joins Board of NIDDK Scientific Counselors
• Second Chan Zuckerberg Grant Awarded to Dr. Benjamin Humphreys
• Dr. Benjamin Humphreys Profiled in Washington People
• Humphreys Elected Secretary-Treasurer to ASCI Council
• Humphreys, Jain and Program Committee meet to Plan Kidney Week 2018
• Humphreys Awarded Chan Zuckerberg Institute Grant
• Humphreys Installed as Joseph Friedman Professor

Education

• Nephrology Fellowship: Brigham and Women’s Hospital, Boston, MA, (2005)
• Internal Medicine Residency: Massachusetts General Hospital, Boston, MA, (2002)
• MD, PhD: Case Western Reserve University, Cleveland, OH, (2000)
• Undergraduate: Harvard College, Cambridge, MA, (1991)

Board Certifications

• Nephrology: Board Certified

Recognition

• Former President, American Society of Clinical Investigation
• Member, Association of American Physicians
• Established Investigator, American Heart Association
• Member, Board of Scientific Counselors for the National Institute of Diabetes and Digestive and Kidney Diseases

Research Interests

The mission of the Humphreys Lab is to understand the cellular and molecular mechanisms of kidney regeneration and thereby identify new therapeutic strategies for humans suffering from kidney disease. A primary focus is on stem cell-based therapeutic approaches. We use mouse as a model system as well as human pluripotent stem cells. The work encompasses two main areas:

1. Developing stem cell-based approaches to treat kidney disease in humans.
2. Understanding the mechanisms of kidney repair and recovery after injury.

Publications

Selected Publications

• B.D. Humphrey. Super chickens, givers, and collective intelligence: the importance of collaboration, teamwork, and mentorship in science. J Clin Invest, 2024 Nov 15;134(22).
• N. Ledru, P.C. Wilson, Y. Muto, Y. Yoshimura, H. Wu, D. li, A. Asthana, S.G. Tullius, S.S. Waikar, G. Orlando and B.D. Humphreys. Predicting proximal tubule failed repair drivers through regularized regression analysis of single cell multiomic sequencing. Nature Communications, 15, 2024; Article number: 1291.
• H. Li, E.E. Dixon, W. Wu and B.D. Humphreys. Comprehensive single-cell transcriptional profiling defines shared and unique epithelial injury responses during kidney fibrosis. Cell Metabolism, 2022; 34(12):1977-1998.
• Y. Muto, E.E. Dixon, Y. Yoshimura, H. Wu, K. Omachi, N. Ledru, P.C. Wilson, A.J. King, E.N. Olson, M.G. Gunawan, J.J. Kuo, J.H. Cox, J.H. Miner, S.L. Seliger, O.M. Woodward, P.A. Welling, T.J. Watnick and B.D. Humphreys. Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis. Nat. Comm., 2022; 13(1):6497.
• H. Wu, R. Gonzalez Villalobos, X. Yao, D. Reilly, T. Chen, M. Rankin, E. Myshkin, M.D. Breyer and B.D. Humphreys. Mapping the Single Cell Transcriptomic Response of Murine Diabetic Kidney Disease to Therapies. Cell Metabolism, 2022; 34(7):1064-1078.
• P.C. Wilson, Y. Muto, H. Wu, A. Karihaloo, S.S. Waikar and B.D. Humphreys. Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease progression. Nat. Commun., 2022;13(1):5253.
• E.E. Dixon, H. Wu, Y. Muto, P.C. Wilson and B.D. Humphreys. Spatially Resolved Transcriptomic Analysis of Acute Kidney Injury in a Female Murine Model. J. Am. Soc. Neph. 2022; 33(2):279-289.
• Y. Muto, P.C. Wilson, N. Ledru, H. Wu, H. Dimke, S.S. Waikar and B.D. Humphreys. Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney. Nat. Commun. 2021; 12:2190.
• Y. Kirita, H. Wu, K. Uchimura, P.C. Wilson and B.D. Humphreys. Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury. Proc. Nat. Acad. Sci., 2020; 117(27):15874-15883.
• M. Chang-Panesso, F.F. Kadyrov, M. Lalli, H. Wu, S. Ikeda, E. Kefaloyianni, M.M. Abdelmageed, A. Herrlich, A. Kobayashi and B.D. Humphreys. FoxM1 drives proximal tubule proliferation during repair from acute kidney injury. J. Clin. Invest., 2019;129(12):5501-5517.
• H. Wu, K. Uchimura, E. Donelly, Y. Kirita, S.A. Morris and B.D. Humphreys. Comparative Analysis of Kidney Organoid and Adult Human Kidney Single Cell and Single Nucleus Transcriptomes. Cell Stem Cell, 2018; 23(6):869-881. *Best of Cell Stem Cell

View full list on PubMed