Benjamin D. Humphreys, MD, PhD

Benjamin D. Humphreys, MD, PhD

Joseph Friedman Professor of Renal Diseases in Medicine and Chief, Division of Nephrology

Additional Titles

  • Professor

Related Links


Patients seen at

Map of location

Center for Advanced Medicine

Mailing Address

Division of Nephrology

  • Mailing Address: 660 S. Euclid Ave., CB 8126
    St. Louis, MO 63110

Dr. Humphreys in the News:


  • Undergraduate: Harvard College, Cambridge, MA, (1991)
  • MD, PhD: Case Western Reserve University, Cleveland, OH, (2000)
  • Internal Medicine Residency: Massachusetts General Hospital, Boston, MA, (2002)
  • Nephrology Fellowship: Brigham and Women’s Hospital, Boston, MA, (2005)

Board Certifications

  • Nephrology: Board Certified


  • President, American Society of Clinical Investigation
  • Member, Association of American Physicians
  • Established Investigator, American Heart Association
  • Member, Board of Scientific Counselors for the National Institute of Diabetes and Digestive and Kidney Diseases

Research Interests

The mission of the Humphreys Lab is to understand the cellular and molecular mechanisms of kidney regeneration and thereby identify new therapeutic strategies for humans suffering from kidney disease. A primary focus is on stem cell-based therapeutic approaches. We use mouse as a model system as well as human pluripotent stem cells. The work encompasses two main areas:

  1. Developing stem cell-based approaches to treat kidney disease in humans.
  2. Understanding the mechanisms of kidney repair and recovery after injury.


Selected Publications

1. N. Ledru, P.C. Wilson, Y. Muto, Y. Yoshimura, H. Wu, A. Asthana, S.G. Tullius, S.S. Waikar, G. Orlando and B.D. Humphreys. Predicting regulators of epithelial cell state through regularized regression analysis of single cell multiomic sequencing. BioRxiv. 2023.

2. H. Li, E.E. Dixon, W. Wu and B.D. Humphreys. Comprehensive single-cell transcriptional profiling defines shared and unique epithelial injury responses during kidney fibrosis. Cell Metabolism, 2022; 34(12):1977-1998

3. Y. Muto, E.E. Dixon, Y. Yoshimura, H. Wu, K. Omachi, N. Ledru, P.C. Wilson, A.J. King, E.N. Olson, M.G. Gunawan, J.J. Kuo, J.H. Cox, J.H. Miner, S.L. Seliger, O.M. Woodward, P.A. Welling, T.J. Watnick and B.D. Humphreys. Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis. Nat. Comm., 2022; 13(1):6497.

4. H. Wu, R. Gonzalez Villalobos, X. Yao, D. Reilly, T. Chen, M. Rankin, E. Myshkin, M.D. Breyer and B.D. Humphreys. Mapping the Single Cell Transcriptomic Response of Murine Diabetic Kidney Disease to Therapies. Cell Metabolism, 2022; 34(7):1064-1078.

5. P.C. Wilson, Y. Muto, H. Wu, A. Karihaloo, S.S. Waikar and B.D. Humphreys. Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease progression. Nat. Commun., 2022;13(1):5253.

6. E.E. Dixon, H. Wu, Y. Muto, P.C. Wilson and B.D. Humphreys. Spatially Resolved Transcriptomic Analysis of Acute Kidney Injury in a Female Murine Model. J. Am. Soc. Neph. 2022; 33(2):279-289.

7. Y. Muto, P.C. Wilson, N. Ledru, H. Wu, H. Dimke, S.S. Waikar and B.D. Humphreys. Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney. Nat. Commun. 2021; 12:2190.

8. Y. Kirita, H. Wu, K. Uchimura, P.C. Wilson and B.D. Humphreys. Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury. Proc. Nat. Acad. Sci., 2020; 117(27):15874-15883.

9. M. Chang-Panesso, F.F. Kadyrov, M. Lalli, H. Wu, S. Ikeda, E. Kefaloyianni, M.M. Abdelmageed, A. Herrlich, A. Kobayashi and B.D. Humphreys. FoxM1 drives proximal tubule proliferation during repair from acute kidney injury. J. Clin. Invest., 2019;129(12):5501-5517.

10. H. Wu, K. Uchimura, E. Donelly, Y. Kirita, S.A. Morris and B.D. Humphreys. Comparative Analysis of Kidney Organoid and Adult Human Kidney Single Cell and Single Nucleus Transcriptomes. Cell Stem Cell, 2018; 23(6):869-881. *Best of Cell Stem Cell

View full list on PubMed