Yoshiharu Muto, MD, PhD

Yoshiharu Muto, MD, PhD

Instructor in Medicine, Division of Medicine

Mailing Address

Division of Nephrology

  • Mailing Address: 660 S. Euclid Ave., CB 8126
    St. Louis, MO 63110

Dr. Muto in the news:

Yoshiharu Muto, MD, PhD, Awarded KidneyCure Carl W. Gottschalk Grant

Research Interests

Elucidating epigenetic mechanisms of various kidney diseases including polycystic kidney diseases. 


MD, PhD: Kyushu University School of Medicine, Japan

Residency and Nephrology Fellowship:  Iizuka hospital, Japan


2023 Carl W.Gottschalk Research Scholar Grant (American Society of Nephrology)

2022   Outstanding Research Paper Award, UJA (United Japanese Researchers Around the World) 

2021 The Osamu Hayaishi Memorial Scholarship for Study Abroad 

2019 Japan Society for the Promotion of Science Postdoctoral Fellowship for Research Abroad

2018 Postdoctoral Fellowship of the Uehara Memorial Foundation 


Y. Muto, E.E. Dixon, Y. Yoshimura, H., Wu, K. Omachi, A.J. King, E.N. Olson, M.G. Gunawan, J.J. Kuo, J.Cox, J.H. Miner, S.L. Seliger, O.M. Woodward, P.A. Welling, T.J. Watnick, B.D. Humphreys. Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysisNature Communications. 2022 Oct 30;13(1):6497. 

Y. Muto*, P.C. Wilson*, N. Ledru, H. Wu, H. Dimke, S.S. Waikar, B.D. Humphreys. Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidneyNature Communications. 2021 Apr 13;12(1):2190 (*Equally contributed)

P.C. Wilson*, Y. Muto*, H. Wu, A. Karihaloo, S.S. Waikar, B.D. Humphreys. Multimodal single cell sequencing of human diabetic kidney disease implicates chromatin accessibility and genetic background in disease progressionNature Communications. 2022 Sep 6;13(1):5253 (*Equally contributed)

Y. Yoshimura, Y. Muto, N. Ledru, H. Wu, K. Omachi, J.H. Miner, B.D. Humphreys. A single-cell multiomic analysis of kidney organoid differentiationProceedings of the National Academy of Sciences of the U.S.A. 2023 May 16;120(20): e2219699120

Y. Muto, A. Nita, M. Nishiyama, T. Moroishi, K.I. Nakayama. Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cellsNature Communications, 2017 Jul 17;8:16114.

Y. Muto*, T. Moroishi*, K. Ichihara, M. Nishiyama, H. Shimizu, Hi. Eguchi, K. Moriya, K. Koike, K. Mimori, M. Mori, Y. Katayama, K.I. Nakayama. Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis. Journal of Experimental Medicine, 2019 Apr 1;216(4):950-965. (*Equally contributed)