Yoshiharu, Muto, MD, PhD, Instructor of Medicine, Division of Nephrology, has been awarded a 2023 Carl W. Gottschalk Research Scholar Grant by the KidneyCure Transition to Independence Grants Program, a foundation of the American Society of Nephrology.
The scholarship program helps young biomedical investigators achieve independent research careers with funding of up to $100,000 per year for two years. The grant will fund Dr. Muto’s project: The Role of Methionine Cycle in Acute Kidney Injury and Repair.
Receiving this grant is an amazing opportunity for early-career scientists who want to target kidney diseases and pursue an academic career as a principal investigator.Yoshiharu, Muto
Muto’s research will address the role of methionine metabolism in remodeling of epigenetic landscape in kidney diseases. He will generate a mouse kidney disease model with perturbation on methionine metabolism and address the mechanism connecting deregulation of methionine cycle and alteration of epigenetic landscape in kidney diseases, identifying a novel therapeutic target.
Muto has been with WashU Nephrology since 2018, when he joined the laboratory of Division Chief, Benjamin Humphreys, MD, PhD, Joseph Friedman Professor of Renal Diseases in Medicine. Visit the Humphreys Lab to learn more about the group’s cutting-edge research.
Recent publications by Dr. Yoshiharu:
- Predicting regulators of epithelial cell state through regularized regression analysis of single cell multiomic sequencing, bioRxiv 2023.
- Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis, Nature Communications, 2022.
- Single Cell Transcriptomics, Innovations in Nephrology, 2022.
- Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease progression, Nature Communications, 2022.
- Recent advances in lineage tracing for the kidney, Kidney International, 2021.
- Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney, Nature Communications, 2021.
See all 2023 Carl W. Gottschalk Research Scholar Grant recipients here.