The Murakami lab’s research focuses on understanding the mechanism of autoimmune kidney diseases and kidney transplant rejection associated with cancer immunotherapies.
Immunotherapy has become a standard therapy for many cancers, but it is associated with a risk of acute kidney injury, resulting in significantly increased mortality. We aim to delineate the roles of antigen-specific T cells in immunotherapy-associated acute kidney injury, using animal models and patient samples, with eventual goal to identify potential therapeutic targets.