The Center of Regenerative Medicine (CRM) at Washington University has awarded Ying Maggie Chen, MD, PhD, a one-year grant for her proposal entitled “Personalized kidney organoid modeling to develop novel treatment for uromodulin-associated chronic kidney disease.”
The CRM is a research collaborative of over 80 faculty members who are dedicated to advancing the science of regenerative medicine and its therapeutic applications. The rapidly developing field of regenerative medicine focuses on developing and applying new treatments to heal tissues and organs. The goal is to restore function lost due to aging, disease, damage or defects by harnessing the body’s own stem cell reservoirs and reprogramming capabilities, or by engineering tissues ex-vivo. See more about the CRM here.
Chen will partner with the CRM Human Cells, Tissues, and Organoids Core to differentiate patient-derived human induced pluripotent stem cells (hiPSC) to autosomal dominant tubulointerstitial kidney disease (ADTKD) kidney organoids, and determine the functional role of a novel cell surface receptor induced by endoplasmic reticulum stress in the ADTKD organoids.
“The novel targeted therapeutic strategy may hold great promise for advancing precision treatment for patients with ADTKD or organelle stress-induced chronic kidney disease in general.”
Ying Maggie Chen
Visit the Y. Maggie Chen Lab website and check out the following articles in WashU Nephrology News to learn more about Dr. Chen’s research:
- Ying Maggie Chen Lab and Collaborators Uncover Biotherapeutic Properties of MANF Protein
- Collaborators Ying Maggie Chen and Srikanth Singamaneni Receive NIDDK R21 Grant to Develop Bio-needle Technology
- Nephrologist Ying Maggie Chen and Bio-Engineer Srikanth Singamaneni Receive OVCR Grant to Develop Bio-needle Technology to Detect AKI Biomarkers
- Physician-Scientist Ying Maggie Chen Elected to American Society for Clinical Investigation
- Dr. Maggie Chen Receives UAB-UCSD O’Brien Center Pilot Award
- Patent Issued for Urinary Biomarkers for ER Stress-Mediated Kidney Disease
- Ying Maggie Chen to Serve on ASN Grants Review Committee
- Dr. Maggie Chen Receives $1.8M Department of Defense Grant to Develop Treatment for FSGS
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