Accomplishment Awards Grant

Andrew Malone, ASCI Young Physician-Scientist, Receives Early Career Development Award

The Division of Nephrology congratulates Assistant Professor of Medicine Andrew Malone, MBBCh, a recipient of a 2021 Early Career Development Award (ECDA) from the Central Society for Clinical and Translational Research (CSCTR), one of the oldest academic medical societies in the Midwest.

The $10,000 grant is awarded to outstanding new investigators to supplement any combination of salary and/or lab support.  Malone was one of six recipients to earn the award for 2021. 

The awardees presented their research abstracts at the Virtual 2021 Midwest Clinical & Translational Research Meeting, held April 12-16, 2021.  Malone’s presentation was titled “Integrating Single Cell RNA-SEQ with Spatially Resolved, Multiplexed Immunofluorescence to Understand Tertiary Lymphoid Organs in Kidney Transplant Rejection.”  See all 2021 ECDA recipients here.

In 2020, Malone received an American Society for Clinical Investigation (ASCI) Council Young Physician-Scientist Award, a prestigious recognition of physician-scientists who are early in their first faculty appointment and have made notable achievements in their research. With these awards, the ASCI encourages and inspires physician-scientists through their participation in the Joint Meeting, the annual meeting of three organizations: The Association of American Physicians, The American Society for Clinical Investigation, and The American Physician-Scientists Association.

Malone’s abstract titled “Plasma Cell Clonotype discordance between rejecting Kidney Transplant Biopsy and paired Peripheral Blood Samples”was presented at the 2020 Joint Meeting.

After receiving his medical degree from the Royal College of Surgeons in Dublin, Ireland, in 2005, Malone completed his residency in internal medicine at Beaumont Hospital and training as a nephrology specialist at the Royal College of Physicians in Ireland.  He completed a nephrology fellowship, as well as post-doctoral training in genetics, at Duke University Medical Center in Durham, NC, in 2011, before coming to Washington University for a fellowship in transplantation nephrology.  Malone joined the WashU Nephrology faculty as Assistant Professor of Medicine in 2015.

His research currently involves the investigation of the transcriptional and molecular responses in acute antibody mediated rejection using single cell RNA-seq methods on rejecting transplant biopsies.  He is the director of the Washington University Kidney Translational Research Core for Transplantation, a large bio-repository of over 12,000 blood, urine, and tissue samples from kidney transplant recipients. He is currently funded by the NIDDK K08 program to study antibody mediated rejection in kidney transplantation using single-cell genomics methods, and he is a site-PI for a number of clinical trials in transplantation. He is a current member of the American Society of Nephrology Policy and Advocacy Committee.

“Andrew possesses a deep intellectual curiosity and has a tireless work ethic – he received a K08 award on his first submission,” says mentor Benjamin Humphreys, MD, PhD, Joseph Friedman Professor of Renal Diseases in Medicine and Chief of WashU Nephrology. “He is now at the forefront of the rapidly evolving field of transplantation genetics and will be a leader in this field for years to come.”

Follow Dr. Malone on Twitter @AndrewFMalone and keep in touch with WashU Nephrology @WUNephrology.