John T. Milliken Department of Medicine
Congratulations to two WashU Nephrology researchers for having their work highlighted on the covers of recent publications. This is the second such cover for each in two years! Meei-Hua Lin, PhD, a senior scientist in the Jeffrey Miner Laboratory, is first author of the article “Mammalian hemicentin 1 is assembled into tracks in the extracellular […]
The American Society of Nephrology debuted a new session at Kidney Week 2018, held last month in San Diego, CA, that featured 29 cutting edge, high-impact publications in the Clinical Journal of the American Society of Nephrology (CJASN) and the Journal of the American Society of Nephrology (JASN) over the past year. The session, called […]
Researchers in the Division of Nephrology are using a state-of-the-art technique called single-cell RNA-sequencing (scRNA-seq) to take kidney biopsy interpretation to a whole new level. Their study, recently published in JASN, presents the first scRNA-seq analysis of a human kidney allograft biopsy. Instructor of Medicine Haojia Wu, PhD, and Assistant Professor of Medicine Andrew Malone, […]
Renal fibrosis, a hallmark of chronic kidney disease (CKD), is characterized by the accumulation of excess extracellular matrix proteins secreted by myofibroblasts. Unfortunately, there are no anti-fibrotic drugs approved for treatment of CKD. A new study headed by researchers in the Humphreys Laboratory in the Division of Nephrology at Washington University, however, is laying the […]
The spectrum of congenital anomalies of the kidneys and urinary tract, known as CAKUT, represents more than 20% of all birth defects and constitutes the largest cause of kidney failure in children. A new study by Dr. Masato Hoshi, a Senior Scientist in the laboratory of Associate Professor of Medicine, Sanjay Jain, Division of Nephrology, […]
Alport syndrome is an inherited disease characterized by progressive loss of kidney function, hearing loss, and eye abnormalities. The syndrome is caused by genetic mutations that affect expression and/or function of the type IV collagen family protein isoforms COL4A3, COL4A4, and COL4A5, which help form the glomerular basement membranes. The onset, symptoms, progression, and severity […]
Thanks to a new study headed by Ying Maggie Chen, MD, PhD, it may soon be possible to diagnose certain human kidney diseases in their earliest stages of development using a noninvasive biomarker of endoplasmic reticulum (ER) stress. The study, Elevated Urinary CRELD2 is Associated with Endoplasmic Reticulum Stress-mediated Kidney Disease, was published online in […]
A new study by WU researchers is one of the largest to simultaneously evaluate 10-year outcomes in three important areas of kidney transplantation: calcineurin inhibitor-based immunosuppression, polyomavirus reactivation, and immune responses to kidney-specific self-antigens fibronectin (FN) and collagen type-IV (Col-IV). The study, headed by Daniel C. Brennan, MD, FACP, Alan A. and Edith L. Wolff […]